Manufacturer: Generic Substance: Anastrozole Pack: 1mg (10 pills)
Selective non-steroidal aromatase inhibitor. Has antitumor activity against estrogen-dependent breast tumors in postmenopausal women. Reduces the content of circulating estradiol. Does not possess progestogen, androgenic and estrogenic activity, does not affect the secretion of endogenous GCS and ISS.
Preparations containing estrogens reduce the pharmacological action of anastrozole, and therefore they should not be administered simultaneously with anastrozole.
Do not prescribe tamoxifen at the same time as anastrozole, since it can weaken the pharmacological action of the latter. In the joint use of anastrozole and tamoxifen in patients with breast cancer, the plasma concentration of anastrozole was reduced by 27% compared to that with anastrozole alone, and the combined administration did not affect the pharmacokinetics of tamoxifen and N-desmethyltamoxifen.
There was no clinically significant effect of anastrozole on the pharmacokinetics and anticoagulant activity of warfarin. In a study in 16 male volunteers, anastrozole had no effect on exposure (estimated by Cmax and AUC) and anticoagulant activity (measured by PV, APTT and thrombin time) of warfarin.
Anastrozole is not prescribed for:
Hypersensitivity to anastrozole;
– indications in the pre-menopausal period;
– therapy with tamoxifen;
– severe renal failure;
– moderate and severe hepatic impairment;
– therapy with estrogen-containing drugs.