Premarin Pfizer

$53.00

Manufacturer: Pfizer Substance: Premarin Pack: 0.625mg (28 pills)

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Substance

Premarin is an estrogen preparation that regulates the work of the female reproductive system. The main active substance of the drug is estrogen, which forms in women secondary sexual characteristics. Getting into the blood, it stimulates the synthesis of proteins and DNA. In this case, the sensitivity of the uterus increases, the total cholesterol level decreases, HDL is increased, normal bone structure remains.

Due to this, such symptoms of menopause as heart palpitations, pressure surges, increased sweating, a sharp change of mood, hot flashes to the upper body, nervousness, irritability, tearfulness, unmotivated panic, increased appetite and weight gain are reduced.

Pharmacological action

It alleviates or eliminates manifestations of climacteric syndrome (sensation of heat, sweating, dizziness, irritability, depressive state), prevents the development of osteoporosis, prevents the involution of the genital organs, normalizes the menstrual cycle in women of childbearing age, lowers testosterone levels in men.

Pharmacodynamics

Regulate the development and preservation of the function of the female reproductive system, the formation of secondary sexual characteristics.

Relieve or stop manifestations of climacteric syndrome – vasomotor disorders, emotional (irritability, anxiety, depression) and urogenital (atrophic vaginitis, progressive diffuse atrophy of the vulva) symptoms.

Prevent the development of postmenopausal osteoporosis, increase the level of HDL, reduce – LDL and total cholesterol, reduce the risk of cardiovascular disease.

Pharmacokinetics

The components of the drug are soluble in water and well absorbed in the digestive tract, penetrate into the target tissues (genitalia, mammary glands, bones, hypothalamus, pituitary gland), cytoplasm and cell nuclei, where they stimulate the synthesis of RNA and protein.

Biotransformation occurs mainly in the liver, estrogens are excreted with bile, but are reabsorbed from the intestine and return to the portal vein system. Water-soluble conjugates of estrogens with acidic properties are ionized in the body and excreted by the kidneys with minimal reabsorption in the tubules.

Side effects

Headache, nausea, vomiting, weight gain, swelling, uterine bleeding, facial skin pigmentation, erythema nodosum, transient elevation of the level of transaminases in blood plasma, hyperbilirubinemia; Allergic reactions (rash); Rarely – hemorrhagic rashes on the skin, neoplasms of the endometrium.

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